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02/06/2012 01:00 AM
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Insight Into Cell Aging Likely Following Discovery Of Extremely Long-Lived Proteins
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One of the big mysteries in biology is why cells age. Now scientists at the Salk Institute for Biological Studies report that they have discovered a weakness in a component of brain cells that may explain how the aging process occurs in the brain...
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02/02/2012 12:00 AM
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The Development Of Parkinson's Cells Visualized By Researchers
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In the US alone, at least 500,000 people suffer from Parkinson's disease, a neurological disorder that affects a person's ability to control his or her movement. New technology from the University of Bonn in Germany lets researchers observe the development of the brain cells responsible for the disease...
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01/31/2012 12:00 AM
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Prion-Like Protein Plays A Key Role In Storing Long-Term Memories
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Memories in our brains are maintained by connections between neurons called "synapses"...
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01/27/2012 12:00 AM
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New Standard For Vitamin D Testing To Ensure Accurate Test Results
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At a time of increasing concern about low vitamin D levels in the world's population and increased use of blood tests for the vitamin, scientists are reporting development of a much-needed reference material to assure that measurements of vitamin D levels are accurate. The report appears in ACS' journal Analytical Chemistry...
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01/26/2012 01:00 AM
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Protein Identified That Contributes To Symptoms Of Parkinson's Disease
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Scientists at the Gladstone Institutes, an independent and nonprofit biomedical-research organization, have identified a protein that exacerbates symptoms of Parkinson's disease - a discovery that could one day lead to new treatments for people who suffer from this devastating neurodegenerative illness...
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01/25/2012 02:00 AM
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First Step In Strategy For Cell Replacement Therapy In Parkinson's Disease
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Induced pluripotent stem cells (iPSC) are a promising avenue for cell replacement therapy in neurologic diseases. For example, mouse and human iPSCs have been used to generate dopaminergic (DA) neurons that improve symptoms in rat Parkinson's disease models...
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01/24/2012 10:00 AM
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Inability To Express Emotion May Be An Early Symptom Of Parkinson's Disease
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Alexithymia, a person's state of deficiency in understanding, processing, or describing emotions, has been strongly linked to depression in both clinical and general populations, and even though symptoms of alexithymia and depression can be partially overlapping, they are not all related to depressive symptoms and therefore highlight the relative independence of the two disorders...
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01/21/2012 12:00 AM
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How Alpha-Synuclein Interacts With Cell Membranes In Parkinson's Disease
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The accumulation of α-synuclein, a small, negatively charged protein, in neural cells, is one of the hallmarks of Parkinson's disease. It has been suggested that oligomeric α-synuclein causes membranes to become permeable, or to form channels on the outer cell membrane...
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01/18/2012 03:00 AM
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Solving The Parkinson's Conundrum: Biologists A Step Closer
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Research by a team in the University's Department of Biology found evidence that movement disorders, including tremor and slowness of movement (bradykinesia), associated with Parkinson's disease (PD) may be due to a defect in energy production in the nervous system. The advance may help to identify young adults who may be susceptible to the disease...
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01/18/2012 02:00 AM
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Researchers Identify Path To Treat Parkinson's Disease At Its Inception
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Imagine if doctors could spot Parkinson's disease at its inception and treat the protein that triggers it before the disease can sicken the patient...
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01/18/2012 12:00 AM
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Cell 'Battery' Found To Play Central Role In Neurodegenerative Disease
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A devastating neurodegenerative disease that first appears in toddlers just as they are beginning to walk has been traced to defects in mitochondria, the 'batteries' or energy-producing power plants of cells...
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01/16/2012 12:00 AM
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How A Motor Protein 'Steps Out'
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Just like people, some proteins have characteristic ways of "walking," which (also like human gaits) are not so easy to describe...
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01/13/2012 01:00 AM
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Iron Intake In Teen Years Can Impact Brain In Later Life
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Iron is a popular topic in health news. Doctors prescribe it for medical reasons, and it's available over the counter as a dietary supplement. And while it's known that too little iron can result in cognitive problems, it's also known that too much promotes neurodegenerative diseases...
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01/11/2012 01:00 AM
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"ORMOSIL" Nanoparticles Hold Promise As A Potential Vehicle For Drug Delivery
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In the images of fruit flies, clusters of neurons are all lit up, forming a brightly glowing network of highways within the brain. It's exactly what University at Buffalo researcher Shermali Gunawardena was hoping to see: It meant that ORMOSIL, a novel class of nanoparticles, had successfully penetrated the insects' brains...
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01/11/2012 12:00 AM
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Lewy Bodies Not Found To Be The Primary Cause Of Cell Death In Parkinson's Disease
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The pathology of Parkinson's disease is characterized by a loss of dopamine-producing neurons in the pars compacta of the substantia nigra (SN), an area of the brain associated with motor control, along with the development of α-synuclein (αS) protein in the form of Lewy bodies (LB) in the neurons that survive...
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01/09/2012 12:00 AM
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Studies Identify Promising Genes And Small Molecules To Use Against Devastating Diseases
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Two related studies from Northwestern University offer new strategies for tackling the challenges of preventing and treating diseases of protein folding, such as Alzheimer's, Parkinson's and Huntington's diseases, amyotrophic lateral sclerosis (ALS), cancer, cystic fibrosis and type 2 diabetes. To do its job properly within the cell, a protein first must fold itself into the proper shape...
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01/04/2012 01:00 AM
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New Theory On Osteoporosis Inspired By Deer Antlers
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The loss of manganese could mean that calcium does not stick to bones and could cause osteoporosis. This is the new theory put forward by researchers at the University of Castilla-La Mancha (UCLM) in Spain after studying deer antlers. The hypothesis published this month in the Frontiers of Bioscience journal still needs to be confirmed by the scientific community...
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01/04/2012 01:00 AM
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Researchers Study Perception Deficits Via "BINGO" Game
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Bingo, a popular activity in nursing homes, senior centers and assisted-living facilities, has benefits that extend well beyond socializing. Researchers found high-contrast, large bingo cards boost thinking and playing skills for people with cognitive difficulties and visual perception problems produced by Alzheimer's disease (AD) and Parkinson's disease (PD)...
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01/04/2012 01:00 AM
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Bingo Helps Researchers Study Perception Deficits
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Bingo, a popular activity in nursing homes, senior centers and assisted-living facilities, has benefits that extend well beyond socializing. Researchers found high-contrast, large bingo cards boost thinking and playing skills for people with cognitive difficulties and visual perception problems produced by Alzheimer's disease (AD) and Parkinson's disease (PD)...
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01/03/2012 09:00 AM
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Parkinson's Disease And Survival - Factors That Have An Impact
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A report in the January issue of Archives of Neurology, one of the JAMA/Archives journals, reveals that demographics and clinical factors seem to be linked to survival in patients with Parkinson disease (PD), and that the presence of dementia is linked to a substantial increase in mortality...
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12/30/2011 12:00 AM
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In Huntington's Disease, Regulatory Enzyme Overexpression May Protect Against Neurodegeneration
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Treatment that increases brain levels of an important regulatory enzyme may slow the loss of brain cells that characterizes Huntington's disease (HD) and other neurodegenerative disorders...
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12/22/2011 12:00 AM
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Innovative New Strategy To Treat Parkinson's Disease
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Stabilizing the cell's power-generating center protects against Parkinson's disease (PD) in a rat model, according to a report published online this week in the Journal of Experimental Medicine (http://www.jem.org). Mitochondria - the energy production center of cells - are damaged in PD, leading to loss of dopaminergic neurons and degeneration of brain function...
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12/20/2011 12:00 AM
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Childhood Disorder Called PKD Linked To Genetic Mutations
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A large, international team of researchers led by scientists at the University of California, San Francisco has identified the gene that causes a rare childhood neurological disorder called PKD/IC, or "paroxysmal kinesigenic dyskinesia with infantile convulsions," a cause of epilepsy in babies and movement disorders in older children...
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12/19/2011 01:00 AM
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Team Discovers Cause Of Rare Disease Childhood Disorder Called PKD Linked To Genetic Mutations
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A large, international team of researchers led by scientists at the University of California, San Francisco has identified the gene that causes a rare childhood neurological disorder called PKD/IC, or "paroxysmal kinesigenic dyskinesia with infantile convulsions," a cause of epilepsy in babies and movement disorders in older children...
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12/16/2011 01:00 AM
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Genetic Factors Can Predict The Progression Of Parkinson's Disease
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Parkinson's disease is marked by the abnormal accumulation of α-synuclein and the early loss of dopamine neurons in the substantia nigra region of the brain. A polymorphism in the promotor of α-synuclein gene known as NACP-Rep1 has been implicated as a risk factor for the disease...
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